Sildenafil is actually a powerful and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) inside the corpus cavernosum, where PDE5 is chargeable for degradation of cGMP. Sildenafil has a peripheral site of action on erections. Sildenafil has no immediate relaxant impact on isolated human corpus cavernosum but potently enhances the … Read More